腺花香茶菜中的对映-贝壳杉烯类二萜化合物

摘要

从昆明产腺花香茶菜(Isodon adenanthus(Diels)Kudo)的地上部分分离到8个化合物,通过波谱分析鉴定,化合物1～3为新的对映-贝壳杉烯类二萜化合物,命名为腺花香茶菜素N、O和P;4个已知二萜为白叶香茶菜戊素(4)、无毛狭叶香茶菜素C(5)、腺花香茶菜甲素(6)和白叶香茶菜乙素(7),同时得到一个高度不饱和脂肪酸9,16-二羰基-10,12,14-三烯-十八碳酸(8).根据ROESY波谱,对化合物4的结构进行了修正.化合物1对K562细胞显示出明显的细胞毒活性(IC50=0.45 μg/mL).%Three new ent-kaurene diterpenoids, adenanthins N, O and P (1-3), and four known diterpenoids,leucophyllin E (4), glabcensin C (5), adenanthin A (6), leucophyllin B (7), together with a highly unsaturated fatty acid, 9,16-dioxo-10,12,14-octadeca-trienoic acid (8), were isolated from Isodon adenanthus (Diels)Kudo. The structure of compound 4 was revised accordingly. Compound 1 showed significant cytotoxic activity against K562 cells with IC50 = 0.45 μg/mL.