Two new cyclic bisbibenzyl derivatives from Hebertus dicranus

摘要

In the present study,two new cyclic bisbibenzyls (1,2) co-occuring with a known compound,isoplagiochins C (3) were isolated from Hebertus dicranus.The structures were determined mainly by extensive 1D and 2D NMR experiments,and the absolute configurations of 1 and 2 were established by the circular dichroism spectrum.Furthermore,all these three rare compounds were tested in vitro for inhibitory activity against the growth of human cancer cell lines (A549,HCT 116,MDA-MB-231,and BEL7404) by the MTT assay,and compound 2 exhibited moderately inhibitory activity with IC50 values ranging from 13.89 to 31.62 μmol·L-1.In conclusion,our results provided a basis for future development and modification of these compounds for cancer therapy..