192Ir 血管内照射防止兔球囊血管成形术后再狭窄

摘要

目的本研究旨在检验192Ir血管内照射对兔球囊血管成形术后再狭窄的作用。rn方法建立兔髂动脉粥样硬化模型，对病变血管行球囊成形术，同时随机分为对照组，10?Gy照射组和18?Gy照射组。以导管导入192Ir放射性导丝对照射组动物的扩张处进行血管内照射。4周后处死动物，取出血管标本，进行病理组织学分析。rn结果 18?Gy照射组最终管腔面积较对照组及10?Gy照射组大(P<0.05)，18?Gy照射组内膜面积较小(P<0.05)。rn结论本动物实验提示192Ir血管内照射可防止球囊血管成形术后再狭窄，其效果与照射剂量相关，其机制涉及抑制新生内膜增殖。%Objective　To examine the effect of endovascular irradiation on restenosis after balloon angioplasty in rabbit. rnMethods　After the establishment of rabbit iliac atherosclerosis model, balloon angioplasty was performed at the lesion segment of the iliac artery. Rabbits were randomly divided into three groups: control group, 10 Gy irradiated group and 18 Gy irradiated group. Endovascular irradiation was performed for irradiated groups at the dilated sites by introducing the 192Ir radioactive guidewire through a catheter. After four weeks, the animals were killed and the target segments were cut down. Histopathologic and morphometric analyses were carried out.rnResults　The mean final lumen area in the 18 Gy group was larger than that in the control or 10 Gy group (P<0.05). The intimal area in the 18 Gy group was smaller (P<0.05).rnConclusions　192Ir endovascular irradiation may prevent restenosis after balloon angioplasty. The effect is related to the delivered dose. The mechanism is involved in inhibition of neointimal proliferation.