Clostridium perfringens is an important zoonotic pathogen that can cause; various diseases in animals and hu -mans . The antimicrobial resistance in Clostridium perfringens is common in animal production . M ost of the resistant genes in Clostridium perfringens locate on the conjngative plasm ids or mobile genetic elements , which accelerate its dissemination . In this article , the resistance mechanism of Clostridium perfringens to the commonly used antimicrobials including tetracyclines , macrolides , lincosamides , streptogramins , cloramphenicol and bacitracin was summarized . In addition , the role the conjngative plasmids or the mobilized transposons played in the horizontal dissemination of the resistant genes in Clostridium perfringens was clarified . The deep understanding on the resistance mechanism of Clostridium perfringens of animal origin can aid the control of this pathogen , which provides the guarantee for the food safety and human health .%目的 产气荚膜梭菌是可引起多种动物和人类疾病的重要人兽共患病原菌.其抗生素耐药性在动物生产中较为普遍,多数耐药基因常位于接合型质粒或流动遗传因子上,加速了产气荚膜梭菌耐药性的扩散.本文概述了动物源产气荚膜梭菌对常用抗生素(四环素类、大环内酯类、林可胺类、链阳霉素类以及氯霉素和杆菌肽锌等)的耐药机制.在此基础上,阐述了接合型质粒和转座子等在产气荚膜梭菌耐药基因水平扩散中的作用.对动物源产气荚膜梭菌耐药机制及扩散机理的深入认识有助于该菌的控制,为食品安全和人类健康提供重要保障.
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