目的 观察联合应用米索前列醇和缩宫素预防阴道分娩产后出血的临床效果.方法 选择2010年1月～2010年12月在三亚中医院经阴道分娩的120例产妇,随机分为研究组和对照组.研究组60例在胎儿娩出后产妇立即舌下含化米索前列醇200μg,并静脉给予5%葡萄糖250mL加缩宫素20U;对照组60例在胎儿娩出后给予产妇静脉注射5%葡萄糖250mL加缩宫素20U.观察两组在产后2小时及24小时内的出血量,并进行比较分析.结果 研究组产后2、24小时平均出血量分别为122.56±42.93mL和205.63±50.27mL;而对照组则为181.64±48.38mL和264.31±51.43mL,两组比较差异有统计学意义(t分别为7.08、5.25,均P<0.01).两组产后出血率比较差异无统计学意义(χ2=0.26,P>0.05).结论 配伍应用米索前列醇和缩宫素预防阴道分娩产后出血的作用明显强于单独使用缩宫素.%Objective To observe clinical therapeutic effect of combination of misoprostol and oxytocin for prevention of postpartum hemorrhage. Methods 120 parturient women who vaginally delivered in our hospital were randomly divided into experimental group( n = 60)and control group (n = 60 ). The parturient women in the experimental group were sublingually administrated misoprostol 200μg immediately after the fetus was delivered out,then the parturient woman was intravenously injected 5％ glucose 250mL + misoprestol 20U immediately. While those partient women in the control group were intravenously injected 5％ glucose 25Oral + misoprostol 230U immediately after the fetus was delivered out. The estimated mean blood loss of the parturient women in both groups at 2h and 24h after delivery was compared. Results In the experimental group, the estimated mean blood loss was 122.56 ±42.93 mL at 2h and 205.63 ±50.27 mL at 24h after delivery respectively,while in the control group the estimated mean blood loss was 181.64 ±48. 382 mL at 2h and 264.31 ±51.43 mL at 24h after delivery respectively. There were significant differences between the two groups in the estimated mean blood loss at 2h and 24h after delivery ( t = 7.08, 5.25 respectively, both P ＜ O. O1 ). In incidence rate of postpartum hemorrhage there was no significant difference between the two groups ( l. 67％ vs 5.00％, x2 =0.26, P ＞0.05 ). Conclusion Combination of misoprostol and oxytocin for prevention of vaginal bleeding after delivery is more effective than single use of oxytucin.
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