Objective To explore the clinical efficacy of short-term intermittent diazepam application in preventing recurrence of febrile seizures ( FS ). Methods 373 children with complex and/or repeated simple FS were prophylactically treated with oral application of diazepam( 0. 3-0. 5mg/kg ) in multicentric hospitals. The clinical features of fever and FS and the adverse drug reactions were dynamically observed before and after intervention. Results Most fevers and recurrence of FS occurred in November and December in these above cases. The primary disease resulting in fever and FS was acute upper respiratory tract infection. The main type of FS was simple FS ( 82. 37% -84.95% ). Prophylaxis rate of repeated FS was 81. 27% with oral application of diazepam, which was significantly different from that before diazepam prophylaxis (X2 = 680. 06, P < 0. 05 ). Adverse reactions of diazepam were mild and alleviated soon without special treatments. Conclusion Oral application of diazepam has the advantages of remarkable curative efficacy on FS prophylaxis and slight adverse drug reactions. The method of short-term intermittent oral application of diazepam can be popularized in basic-level medical institutions.%目的 探讨短程间歇性应用地西泮对预防热性惊厥复发的临床疗效.方法 对来源于多中心的复杂性热性惊厥和/或反复单纯性热性惊厥的373例患儿口服地西泮(0.3~0.5mg/kg),动态观察地西泮干预前、后患儿发热及热性惊厥发生的临床特点以及药物不良反应等指标.结果 患儿发热及出现热性惊厥发作的高峰月份为每年的11和12月份,疾病以急性上呼吸道感染为主,热性惊厥发作形式主要为单纯性(82.37%~84.95%).地西泮干预对热性惊厥复发的防治率达81.27%,同干预前比较有差异有统计学意义(χ2=680.06,P<0.05),而不良反应轻微并可自行缓解.结论 短程间歇性应用地西泮预防热性惊厥复发具有疗效显著及不良反应轻微的优点,适宜在基层医疗机构推行.
展开▼
