Estimate of the Lowest Dose of Diazepam Required to Treat Soman-InducedConvulsions in Rhesus Monkeys Pretreated with Pyridostigmine and Treated with Atropine, Pralidoxime Chloride and Diazepam

摘要

The purpose of this study was to estimate the minimal dose of intramuscularlyadministered diazepam to limit soman-induced convulsions in rhesus monkeys pretreated with pyridostigmine and treated with atropine and 2-PAM. Eleven rhesus monkeys were pretreated with four oral doses of pyridostigmine administered at eight-hour intervals before intramuscular administration of 5 LD50 of soman. All of the animals were-treated with atropine and 2-PAM chloride one minute following exposure to soman. Nine of the eleven animals were also treated with varying intramuscular doses of diazepam immediately following the injection of PAM-C1. The clinical course of recovery of soman intoxication was monitored to identify the presence or absence of tonic-clonic convulsive movements. Two soman-exposed animals that received no diazepam convulsed severely and ultimately lapsed into a prolonged coma. In the two animals treated with 50 ug/kg diazepam,.convulsions were prevented in one animal but not the other. When four animals were exposed to soman and treated with atropine, 2-PAM and 100 ug/kg of diazepam, brief convulsions occurred in only one of the four diazepam, rhesus monkeys, intramuscular, anticonvulsant, laboratory animal