盐酸咪唑苯脲复乳制备条件的优化研究

摘要

To optimize the recipes and conditions of preparing imidocarb dihydrochloride multiple emulsion,the best oil phase and emulgator and their concentrations,theoil-water proportion and emulsification conditions were determined for original emulsion preparation by means of orthogonal experiments as well as single element experiments at first.Then the best emulgator of outside aqueous phase,the volume ratio of aqueous phase and original emulsion,stabilizer of inside aqueous phase and it's dosage,and emulsification conditions were screened out for preparating imidocarb dihydrochloride multiple emulsion.The results showed that the optimum conditions for original emulsion preparation were obtained by using mineral oil as oil phase,10% of OP-10 as emulgator, 7:3 of oil-water proportion and the emulsification conditions were 40 ℃,3 min and 10000 rpm.The optimal choices for multiple emulsion preparation were 7%of emulgator for outside aqueous phase,5:5 of aqueous phase and original emulsion,10% gel as stablizer and 25 ℃,1 min and 4000 rpm emulsification.The optimized the recipes and conditions of preparing imidocarb dihydrochloride multiple emulsion were determined.%为了优化盐酸咪唑苯脲复乳制剂的配方和乳化条件,首先通过单因素筛选试验,确定最佳油相和乳化剂的种类、浓度及油水比例、乳化条件确定初乳制备条件;再通过选择不同外水相乳化剂、外水相与初乳体积比、内水相稳定剂与用量以及乳化条件,确定复乳制备条件.结果表明,选择白油作为油相、10%的OP-10为乳化剂、油相和水相比例7:3,乳化温度为40℃,乳化时间为3 min,乳化速度为10000 rpm时为制备乳剂的最佳条件;选择7%浓度的外水相乳化剂,外水相与初乳体积比为5:5,选择10%明胶液稳定剂,采用25℃、1 min、4000 rpm的乳化条件制备的复乳制剂效果最佳,研究初步获得了盐酸咪唑苯脲复乳制剂配方和乳化条件.