制剂新技术提高药物溶解性和渗透性的研究进展

摘要

溶解性和渗透性是影响药物药动学和药效学的重要因素,是决定先导化合物能否开发成药物的关键因素之一,如何提高药物的溶解性和渗透性成为了新药开发和老药改造的重要内容.本文阐述了6种制剂技术改善药物溶解性和渗透性的原理、各种制剂技术的利弊以及制剂技术在提高药物溶解性和渗透性方面面临的挑战,同时对制剂技术在提高药物溶解性和渗透性方面的发展方向和策略进行了展望.%Solubility and permeability are important factors for influencing the pharmacokinetics and pharmacodynamics of drugs,and they are the key factors that determine the development of lead compounds into drugs.Therefore,how to improve the solubility and permeability of drugs has become an important part of new drug development and transformation of old drugs. In this paper, the recent new preparation techniques for improving drug solubility and permeability are summarized. The principles of various new preparation technologies to improve drug solubility and permeability are introduced. The advantages and disadvantages of various new preparation techniques and the feasibility of their application to the field of veterinary drugs are analyzed. We discussed challenges and problems of improving the solubility and permeability of drugs by new preparation technologies and prospected for the development direction and strategies of new preparation technologies to improve drug solubility and permeability.