再次TURP患者前列腺组织微血管密度、血管内皮生长因子和雄激素受体的表达及意义

摘要

Objective To discuss microvessel density (MVD) and expression of vascular endothelial growth factor(VEGF), androgen receptor(AR) in the prostates of men who received re-operation after TURP. Methods Fifty cases were performed re-TURP (re-TURP group) and the remaining 50 cases served as controls. 150 specimens were collected. Sections were stained for CD34 and VEGF, AR by immuno-histo-chemistry(S-P). Statistical analysis of the results was performed using t-test or Pearson Chi-Square test Results The expression of VEGF, AR and MVD were significantly higher in the re-TURP group compared to controls(P<0. 05),but in re-TURP group, difference in VEGF and AR expression as well as MVD were not found to be significantly different between the first and the second TURP(P>0.05). Conclusion Over expression of VEGF and AR as well as high MVD in prostatic tissue might play an important role in the pathological process of BPH after TURP.%目的 探讨再次TURP患者前列腺组织微血管密度(MVD)、血管内皮生长因子(VEGF)和雄激素受体(AR)表达的临床意义.方法 再次TURP手术患者50例.选取2次手术标本(再次TURP组),50例首次手术患者标本作为对照组.采用免疫组织化学S-P法检测标本组织中CD_(34)、VEGF、AR的表达,通过血管内皮特异的CD_(34)染色计数MVD值.统计学比较3组标本MVD、VEGF、AR的表达水平.结果 再次TURP组1、2次手术标本和对照组标本MVD值分别为35.83±20.92、32.16±16.65和20.56±6.99,VEGF阳性表达率分别为82.0%(41例)、84.0%(42例)和60.0%(30例),AR阳性表达率分别为84.0%(42例)、88.0%(44例)和64.0%(32例),再次TURP组首次标本MVD值、AR及VEGF阳性表达率均高于对照组,差异有统计学意义(P<0.05);再次TURP组2次手术标本间各指标差异无统计学意义(P>0.05). 结论 BPH患者前列腺组织中高MVD值及AR、VEGF高表达是导致TURP术后复发及再次手术的重要原因之一.