卵巢占位性病变的超声造影时间-强度曲线研究

摘要

目的 分析卵巢占位性病变超声造影时间强度曲线参数,初步探讨其诊断及鉴别诊断卵巢占位性病变的临床价值.方法 对75个卵巢占位性病灶进行超声造影检查,根据患者手术病理及随访结果 将病例分为良恶性两组,比较两组病例时间-强度曲线(TIC)参数并分析其ROC曲线.结果 超声造影共检查41个良性病灶,34个恶性病灶,其TIC参数中上升支斜率、始增时间、峰值时间、始增强度、峰值强度、曲线下面积在良恶性两组病变中差异有统计学意义(P＜0.05).初步确定上升支斜率、峰值强度诊断阈值分别为2.5及34.66 dB.结论卵巢占位性病变的TIC定量参数分析有助于良恶性病变的鉴别诊断；初步认为上升支斜率、峰值强度有较高的诊断价值.%Objective To investigate the diagnostic value of the contrast-enhanced ultrasound in ovarian space-occupying lesions. Methods The ultrasound contrast agent(SonoVue) was used in the examination of 75 ovarian space-occupying lesions. The CEUS parameters of time-intensity curve(TIC) of the lesions and the ROC curve analysis were studied in benign and malignant group proved by pathology and follow-up observation. Results 41 benign focuses and 34 malignant focuses were investigated by CEUS. The TIC parameters of the Peak time, the peak intensity, the initial time, the initial intensity, the slope of the ascending branch and the area under the curve had statistical significance difference between the two groups(P<0. 05). The diagnostic point of the slope of the ascending branch and the peak intensity is 2. 5 and 34. 66 Db respectively, According to the ROC curve analysis. Conclusions Parameters of CEUS can provide more objective information in distinguishing ovarian malignant from benign ovarian lesions. The slope of the ascending branch and the peak intensity are valuable in differential diagnosis.