FibroScan对原发性肝癌的诊断价值

摘要

Objective To investigate the diagnostic value of liver stiffness (LS) measured by FibroScan in hepatocellular carcinoma (HCC).Methods A total of 572 patients with HCC indicated for biopsy or imaging investigations,572 cirrhotic patients were enrolled,serum biomarkers were obtained from the patients on the day of FibroScan.The research was designed to study the performance of LS measured by FibroScan for the diagnosis of HCC,the diagnostic performance of the LS and biochemical parameters were assessed using ROC curves analysis.Results HCC patients had significantly higher LS than cirrhotic patients(39.5 kPa vs 11.8 kPa,P ＜0.001).The cut-off of LS in diagnosing presence of HCC,as determined with the maximal sum of sensitivity and specificity,was 16.95 kPa,the sensitivity and specificity were 80.4％ and 80.7％,respectively.The cut-off,as determined with specificity more than 90％,was 23.7 kPa,the sensitivity and specificity were 65.7％ and 90.2 ％,respectively.Conclusions LS with FibroScan may serve as a noninvasively measurement for diagnosis of HCC,with a relative high level of accuracy.%目的 探讨FibroScan所测肝脏硬度(liver stiffness,LS)对原发性肝癌(hepatocellular carcinoma,HCC)的诊断价值.方法 对572例HCC患者、572例肝硬化患者同时行FibroScan检查、血清标志物检测,HCC组以影像学检查或肝组织病理学检查结果为金标准,分析各检测变量诊断HCC的ROC曲线,探讨FibroScan所测LS对HCC的诊断价值.结果 HCC组的LS明显高于肝硬化组(39.5 kPa对11.8 kPa,P＜0.001);LS诊断HCC的最佳临界值为16.95 kPa,灵敏度为80.4％,特异度为80.7％.以特异度＞90％为条件选择最佳临界点,LS为23.7 kPa,灵敏度和特异度分别为65.7％、90.2％.结论 FibroScan测量LS诊断HCC具有较好的准确性.