伴雷诺现象的系统性红斑狼疮43例分析

摘要

Objective:To explore the clinical manifestationsof the patients with systemic lupus erythematosus(SLE) with Raynaudˊs phenomenon.Methods:We retrospectively analyzed the clinical manifestations of 43 SLE patients with Raynaudˊs phenomenon and com-pared with those of 96 SLE patients without Raynaudˊs phenomenon in system injury and laboratory examination.Results: As compared with SLE patients with Raynaudˊs phenomenon, the SLE patients with Raynaudˊs phenomenon were more likely to have myalgia/myopathy、erythra、arthralgia、cardiac involvement、pulonary hypertension(10.42%vs25.58%、59.38%vs81.40%、10.42%vs46.51%、32.29%vs51.16%、4.17%vs27.91%. P<0.05) positive antinuclear antibodics、positive anti-dsDNA antibodies、positive anti-RNP antibod-ies、positive anti-Sm antibodies、 elevated serum level of gamma-globumin (62.50%vs81.39%、23.96%vs60.46% 、11.46%vs20. 93%、47.92%vs60.46%. P<0.05) There were no significant differences in nephritis、neuropsychiatric and hematologic alterations be-tween two groups.Conclusion:The Raynaudˊs phenomenon in SLE patients seems susceptible to nephritis alteration、pulmonary hyperten-sion、Cardiac involvement and immunologic abnormalities.We should pay special attention to the function of heart and lung and pulmonary hypertension , in order to avoid unfavorable consequences.%目的：探讨伴雷诺现象（ RP）的系统性红斑狼疮（ SLE）患者的临床特征。方法：对2011～2013年在我院住院的伴RP的43例SLE患者临床表现进行回顾性分析，并与96例无RP的SLE患者在临床表现、实验室检查等方面进行比较。结果：与无RP组相比．有RP组出现肌痛／肌炎、皮疹、关节痛（炎）、心脏受累和肺动脉高压的几率明显增高（分别为10．42％～25．58％、59．38％～81．40％、10．42％～46．51％、32．29％～51．16％、4．17％～27．91％。 P＜0．05）抗核抗体、抗RNP、抗Sm及γ－球蛋白升高的阳性率也明显增高（分别为62．50％～81．39％、23．96％～60．46％、11．46％～20．93％、47．92％～60．46％。 P＜0．05）、而2组患者肾脏受累、神经系统受累及血液系统受累的发生率差异无显著性（ P均＞0．05）。结论：SLE患者出现雷诺现象提示较易发生肾脏受累、肺动脉高压、心脏受累和免疫学异常，对伴雷诺现象的SLE患者应注意早发现、以便早期诊断和治疗，以防不良后果发生。