参麦注射液对晚期肺癌气阴两虚证和气虚痰湿证患者血清 VEGF、bFGF 水平的影响

摘要

目的：探讨参麦注射液对不同证型晚期肺癌患者血管内皮细胞生长因子（ VEGF）及碱性成纤维细胞生长因子（ bFGF）水平的调节作用。方法：将符合纳入标准的51例晚期肺癌患者，辨证分别归于气阴两虚证组及气虚痰湿证组，两组均给予参麦注射液静脉输注，治疗两个疗程。采用双抗夹心酶联免疫吸附法（ ELISA）检测治疗前后血清VEGF和bFGF含量。结果：治疗后，两组患者血清bFGF水平均有所下降，差异有显著性；气阴两虚证组的VEGF水平亦有所下降，差异显著；气阴两虚证组的VEGF和bFGF下降较气虚痰湿证组显著；治疗前后两组VEGF和bFGF水平均呈正相关。结论：参麦注射液能有效地抑制气阴两虚证晚期肺癌患者的血清VEGF、bFGF水平，且可能增强气阴两虚证晚期肺癌的VEGF和bFGF的协同作用。%Ob jective:To analyze the regulatory effect of Shenmai injection on VEGF and bFGF levels in ad-vanced stage lung cancer patients with deficiency of qi and yin syndrome or qi deficiency and phlegm -dampness syndrome.Methods:51 Cases advanced stage lung cancer patients who met the inclusive standards of western medication were divided into deficiency of qi and yin syndrome group and qi deficiency and phlegm -dampness syndrome group according to differentiation standards in TCM .Both groups were given Shenmai injection (50mL) into 250mL 5%GS intravenously for 14consecutive days among the 21-day period,both groups repeated 2 treat-ment periods .The contents of VEGF and bFGF were assayed by ELISA in the patients before and after treatment . Results:After the treatment,the level of serum bFGF in both groups was significantly decreased (P<0.001),the level of VEGF in deficiency of qi and yin syndrome group was also significantly decreased ,which had statistical difference to compare with before treatment (P<0.01).The range of decline of VEGF and bFGF in deficiency of qi and yin syndrome group was more apparent (P=0.038,P=0.045).Serum VEGF level was positively correla-ted with serum bFGF level in both groups .Conclusion: Shenmai injection can inhibit serum VEGF and bFGF levels more effectively in advanced stage lung cancer patients , that probably enhance the synergistic effect of VEGF and bFGF in advanced stage lung cancer patients with deficiency of qi and yin syndrome .