丹芪祛瘀止痛颗粒对慢性萎缩性胃炎癌前病变患者胃黏膜CDX1、CDX2表达的影响

摘要

目的:观察丹芪祛瘀止痛颗粒治疗PLGC患者的临床疗效及其对胃黏膜CDX1、CDX2表达的影响.方法:68例PLGC患者按照随机数字表法分为对照组(34例)和观察组(34例),对照组给予胃复春片治疗,观察组给予丹芪祛瘀止痛颗粒治疗,治疗3个月.疗程结束后观察临床症状、胃镜观察胃黏膜改变情况及免疫组化方法检测2组患者胃黏膜组织中CDX1、CDX2的阳性表达.结果:观察组总有效率为88.2％,对照组总有效率为64.7％,2组患者临床疗效比较具统计学意义(P＜0.05).观察组胃镜总有效率为85.3％,对照组总有效率为58.8％,2组胃镜疗效比较具统计学意义(P＜0.05).2组治疗前胃黏膜组织CDX1蛋白的阳性表达率分别为82.35％、79.41％ (P ＞0.05),治疗后阳性表达率分别为41.18％、67.65％ (P ＜0.05),观察组治疗前后比较差异具统计学意义(P＜0.01);2组治疗前胃黏膜组织中CDX2蛋白的阳性表达率分别为88.24％、91.18％ (P＞0.05);治疗后阳性表达率分别为20.59％、55.88％ (P＜0.01),两组治疗前后比较差异均具统计学差异(P＜0.01);观察组较对照组阳性表达率下降更明显.结论:丹芪祛瘀止痛颗粒可改善患者的临床症状及胃黏膜病变,下调CDX1、CDX2表达水平.%Objective:To observe the curative effect of Danqi Quyu Zhitong Granule on patients with PLGC and influence on expressions of CDX1,CDX2 in gastric mucosa.Methods:64 Patients of PLGC were randomly divided into control group (34 cases) and observation group (34 cases) according to the diagnostic criteria and inclusion criteria,the observation group was given Danqi Quyu Zhitong Granule,the control group treated with Weifuchun tablet,they were treated for three months.To observe the clinical symptoms changes and the change of endoscopic mucosa and the positive expression rate of CDX1,CDX2 proteins in gastric mucosa by immunohistochemical methods at the end of the course.Results:The total effective rate of observation group was 88.2％,the control group total effective rate was 64.7％,difference was statistically significant between the two groups (P ＜0.05).The total effective rate of gastroscopy in the two groups were respectively 85.3％ and 58.8％,the difference was statistically significant between the two groups (P ＜ 0.05).The positive expression rates of CDX1 protein in gastric mucosa of the two groups patients were 82.35％ and 79.41％ before treatment (P ＞0.05) and the positive rates were 41.18％ and 67.65％ after treatment(P ＜0.05),the difference was statistically significant in the observation group compared with pre-treattment (P ＜ 0.01);The positive expression rates of CDX2 protein in gastric mucosa were 88.24％ and 91.18％ before treatment (P ＞ 0.05) and the positive rate were 20.59％ and 55.88％ respectively(P ＜ 0.01) after treatment,the difference was statistically significant in both groups after treatment compared with pre-treattment (P ＜ 0.01),the effect of observation was more significant (P ＜ 0.05).Conclusion:Danqi Quyu Zhitong Granule can improve the clinical symptoms and the changes of gastric mucosa,down-regulation the expressions of CDX1 and CDX2 proteins.