use of a first-line therapy and a second-line therapy for treating a patient having a disease, disorder or condition associated with elevated tumor antigen expression, and a composition for reducing or preventing an adverse effect associated with administering a genetically modified cell to express a car.

摘要

1/1 summary “methods for treating a patient having a disease, disorder or condition associated with a high expression of a tumor antigen, and for reducing or preventing an adverse effect associated with administration. The invention of a genetically engineered cell to express a carcass provides the compositions and methods for treating cancer in a patient. In one embodiment, the method comprises first-line therapy, comprising administering to a patient in need thereof a genetically engineered cell to express a car in which the car comprises an antigen-binding domain, a transmembrane domain, a costimulatory signaling region, and a cd3 zeta signaling domain and monitoring of post-infusion cytokine levels T-cells to determine the type of second-line therapy appropriate to treat the patient as a consequence of the presence of the T-cell in the patient.