参附注射液对冠心病心绞痛患者氧化型低密度脂蛋白和一氧化氮水平的影响

摘要

背景:内皮功能障碍与冠心病之间的关系越来越受到重视.氧化型低密度脂蛋白(ox-LDL)及一氧化氮(NO)的改变对内皮功能产生一定的影响,对冠心病患者的预后起着重要的作用,中药在治疗此类疾病时对这些指标的改善起到哪些作用呢?目的:观察参附注射液对冠心病心绞痛患者ox-LDL及NO的影响.设计:随机对照的研究.单位:解放军第二○五医院内二科,锦州医学院附属第一医院心血管内科.对象:解放军第二○五医院,锦州医学院附属第一医院住院及心血管专科门诊收治的冠心病心绞痛患者60例.方法:60例冠心病心绞痛患者随机分为对照组和治疗组,两组均予西药常规治疗,治疗组加用参附注射液静滴.分别检测两组治疗前后血清ox-LDL和NO水平.主要观察指标:治疗后两组患者ox-LDL及NO水平变化情况.结果:对照组治疗前后ox-LDL,NO的值分别为(6.01±0.81),(5.78±0.55)μg/L;(11.39±1.15),(12.89±1.80)μmol/L,其变化差异无显著性意义(P＞0.05),而治疗组治疗前后上述两指标的值则分别为(6.61±0.87),(4.01±0.82)μg/L;(11.83±1.25),(17.20±1.52)μmol/L,差异有显著性意义(P＜0.05).结论:参附注射液可升高冠心病心绞痛患者NO水平、降低ox-LDL水平,从而改善血管内皮功能.%BACKGROUND: The relation between functional disorder of endothelium and coronary heart disease(CHD) has been paid more attention day by day. Changes of oxidized low density lipoprotein (ox-LDL) and nitrogen monoxide(NO) may effect endothelial function to a certain degree and thus play an important role in prognosis of CHD. What effect do Chinese herbal medicine have on improvement of these indexes?OBJECTIVE: To observe effect of shenfu injection on ox-LDL and NO in patients with angina pectoris of CHD.DESIGN: A randomized controlled research.SETTING: Second Medical Department of the 205 Hospital of Chinese PLA. Cardiovascular Department of First Hospital Affiliated to Jinzhou Medical College.PARTICIPANTS: Sixty hospitalized patients and specialized cardiovascular outpatients with angina pectoris of CHD from the 205 Hospital of Chinese PLA and First Hospital Affiliated to Jinzhou Medical College.METHODS: Sixty patients with angina pectoris of CHD were randomized divided into two groups: control group and therapy group. Patients in control group were given regular treatment with western medicine. Patients in therapy group were given additional shenfu injection. Ox-LDL and NO were tested respectively before and after treatment in two groups.MAIN OUTCOME MEASURES: Changes of ox-LDL and NO before and after treatment in two groups.RESULTS: The contents of ox-LDL and NO before and after treatment in control group were respectively(6.01 ± 0. 81 ) and(5.78 ± 0. 55) μg/L, and (11.39 ± 1.15) and(12.89 ± 1.80) μmol/L. There was no significant difference( P ＞ 0. 05) . However, the results before and after treatment in therapy group were(6.61 ± 0. 87)and(4.01 ± 0.82) μg/L, and (11.83 ± 1.25)and(17.20 ± 1.52) μmol/L. There was significant difference( P ＜ 0. 05).CONCLUSION: Shenfu injection may increase NO and decrease ox-LDL in patients with angina pectoris of CHD so to improve the function of vascular endothelium.