晚发型阿尔茨海默病与α2巨球蛋白的研究动态

摘要

AIM: To investigate the relationship between Alzheimer disease(AD) and alpha 2-macroglobulin(α2M) initially so as to provide evidence for the pathogenesis of late-onset AD.METHODS: The significance of α2M in the late-onset AD was revealed through pathology of α2M in AD and the polymorphism of α2M in AD patients.RESULTS: The association between AD and α2M region on the twelfth chromatosome was analyzed with the genic linkage, and pathological symptom of α2M in AD patients was supported by many evidences. Two polymorphism sites of α2M were located on the 12P12-13, which could increase more risks to AD patients.CONCLUSION: It is significant to investigate the frequency, mutation,polymorphism and expression of gene α2M for the pathogenesis of late-onset AD and its genic diagnosis.%目的:初步探讨晚发型阿尔茨海默病(Alzheimer disease,AD)与α2巨球蛋白的关系,为晚发型AD发病机制提供依据.方法:通过α2巨球蛋白在AD病理中的表现和AD患者中α2巨球蛋白的多态性,揭示α2巨球蛋白在晚发型AD中的意义.结果:AD与12号染色体上α2M区的关联是通过基因连锁分析得到的,有大量的数据支持α2巨球蛋白基因在AD患者病理中的表现.在12P12-13位置上有两个α2巨球蛋白多态性位点,可增加AD的患病危险性.结论:研究α2巨球蛋白基因的频率、突变、多态性或表达对晚发型AD的发病机制和基因诊断有重要意义.