CD40/CD40配体结合产生共刺激信号对干细胞及B细胞增殖分化的影响

摘要

OBJECTIVE: To investigated influence of co-stimulatory signal produced by CD40/CD40 ligand (CD40L) on proliferation and differentiation of leukemic stem cells and B cells as well as the role of CD40L anti-leukemia.DATA SOURCES: We searched Pubmed database and Springer database for the related literatures on CD40/40L, leukemic stem cell and leukemia published from January 1995 to December 2005, using the keyword "CD40, 40L, leukemic stem cell, leukemia" in English.STUDY SELECTION: We focused on published data that included the literatures of experimental groups and control groups, excluded obviously no random experiments, no random clinical studies and repeated researches.DATA EXTRACTION: We collected 30 experimental articles on influence of co-stimulatory signal produced by CD40/CD40L on proliferation and differentiation of leukemic stem cells and B cells as well as the role of CD40L anti-leukemia. Twenty-three articles that met inclusion criteria, excluded 7 articles were the same research ones.DATA SYNTHESIS: Twenty-three trials included influence of co-stimulatory signal produced by CD40/CD40L on proliferation and differentiation of leukemic stem cells, B cells and prognosis of leukemia, and the treatment of leukemic patients by CD40L. We analyzed the influence and role of co-stimulatory signal produced by CD40/CD40L on proliferation and differentiation of leukemic stem cells, B cells and leukemia.CONCLUSION: The evidence conformed that co-stimulatory signal produced by CD40/CD40L promoted proliferation and differentiation of leukemic stem cells , B cells, and it is important for the occurrence,progress and prognosis of leukemia. CD40/CD40L plays a crucial part in immune response, and proves wide application in the immune therapy of leukemia.%目的:探讨CD40/CD40配体结合产生的共刺激信号对干细胞、B细胞增殖分化的影响及CD40配体抗白血病的作用.资料来源:检索Pubmed和Springer数据库1995-01/2005-12与CD40/CD40配体、白血病干细胞及白血病相关文献,检索词为"CD40,CD40L,Leukemia,Leukemic stem cell",限定文献语种为英语.资料选择:对资料进行初审,选取实验包括实验组和对照组的文献,排除明显不随机实验和临床研究及重复性研究.资料提炼:共收集到30篇关于CD40/CD40配体结合产生的共刺激信号对干细胞、B细胞增殖分化的影响及CD40配体抗白血病作用的实验文章,23篇符合纳入标准,排除的7篇均为同一研究.资料综合:综合23个实验包括CD40/CD40配体对白细胞干细胞、B细胞增殖分化的影响,对白血病患者预后的影响及CD40配体对白血病患者的治疗作用,并对CD40/CD40配体对白细胞干细胞、B细胞及白血病患者的影响、作用进行分析.结论:CD40/CD40L结合所产生的共刺激信号可促进白血病干细胞和B细胞的增殖分化,与白血病的发生、发展和预后有密切关系.CD40/CD40L在免疫应答中起关键作用,广泛应用于白血病的免疫治疗.