羟丙基壳聚糖纳米微粒的制备

摘要

将壳聚糖与环氧丙烷反应,通过控制反应条件制备出取代度为0.56的羟丙基壳聚糖.改性后的羟丙基壳聚糖水溶性增强,将其配制成适当质量浓度的水溶液,利用离子凝胶法,与一定质量浓度的多聚磷酸钠反应,形成了粒径在500～700nm的羟丙基壳聚糖纳米微粒,透射电镜图像显示制备出的纳米微粒形状规整.%Hydroxypropyl-chitosan with substitution degree of 0.56 is prepared by the reaction of chitosan and epoxypropane by controlling condition. The water solubility of modified hydroxypropyl-chitosan is enhanced. When suitable concentration of hydroxypropyl-chitosan water solution responds to certain concentration of sodium polyphosphate based on ion gel method, the hydroxypropyl-chitosan nano-spheres with particle size of 500-700nm are obtained. Transmission electron micrograph shows that the shape of prepared hydroxypropyl-chitosan nano-sphere is uniform.