BACKGROUND: Transdermal drug delivery system provides a convenient and effective way for the delivery of peptides and proteins.OBJECTIVE: To develop a microcontroller-based transdermal drug delivery system, which can provide non-invasive trasdermal drug delivery, maintain the activity of drugs and improve the bioavailability of drugs.METHODS: The microcontroller was used as the control core. Enhancement techniques such as electroporation, iontophoresis and sonophoresis were added into the delivery of proteins. The skin barrier was overcome at different aspects, and the absorption of transdermal drug was increased. Besides, synergistic effect of these three enhancement techniques was achieved via reasonable design based on software and hardware, as well as the efficiency of drug delivery was improved.RESULTS AND CONCLUSION: The developed prototype of transdermal drug delivery system was easy to operate. The non-invasive trasdermal drug delivery can improve patients' compliance and can be used for trasdermal drug delivery with a variety of drugs by adjusting the treatment parameters, as well as provide the potential for individualized therapy.%背景:经皮给药技术为蛋白质多肽类药物的导入提供了一种方便有效的方式.目的:研制一种基于微控制器的经皮给药系统,实现药物经皮无创导入的同时维持药物的活性,提高药物的生物利用度.方法:经皮给药系统以微控制器为核心,采用电致孔导入技术,电离导入技术和超声波导入技术从不同角度克服皮肤屏障,促进药物经皮吸收,在软硬件上合理的设计实现3 种机制的协同作用,提高药物导入的效率.结果与结论:试制出经皮给药系统样机,该系统操作简便,以无创的方式经皮给药可以提高患者的依从性,通过各治疗参数的调节,可用于多种药物的经皮导入,为实现个体化治疗提供可能.
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