中药促成骨细胞增殖和分化的机制与作用

摘要

背景:中药促进成骨细胞增殖和分化的效果已经得到肯定,其在细胞分子水平的药理机制研究取得了很大进展.目的:对国内外应用中药诱导成骨细胞增殖和分化的药理机制研究进展作一综述.方法:应用计算机检索CNKI,Pubmed 和sciencedirect 数据库中2001-01/2010-12 关于中药促进成骨细胞增殖和分化机制研究的文章,在标题和摘要中以"中药,成骨细胞,增殖,分化,机制"或"Chinese herbs,osteoblast,proliferation,differentiation,mechanism"为检索词进行检索.初检得到176 篇文献,最终选择30 篇文献进行综述.结果与结论:中药通过对成骨细胞基因、信号通路、细胞因子和OPG/RANK/RANKL 系统的调控,以及类雌激素样作用促进成骨细胞增殖和分化,其作用机制明确,将中药引入骨组织工程领域具有良好的发展前景.%BACKGROUND: It is confirmed that traditional Chinese medicine can improve osteoblast proliferation and differentiation. Cellmolecular research on the pharmacological mechanism behind this has made great progress.OBJECTIVE: To summarize the research progress on the mechanisms of osteoblasts proliferation and differentiation induced bytraditional Chinese medicine at home and abroad.METHODS: An online search of CNKI, PubMed and ScienceDirect databases was performed for articles on the mechanism ofosteoblast proliferation and differentiation induced by traditional Chinese medicine, published between January 2000 andDecember 2010, using keywords of "traditional Chinese herbs, osteoblasts, proliferation, differentiation and mechanism". A total of176 articles were collected after initial search, and 30 of them were retained.RESULTS AND CONCLUSION: Traditional Chinese medicine can improve osteoblast proliferation and differentiation byregulating the genes, signal pathways, cytokines, OPG/RANK/RANKL system of osteoblasts and estrogen-like biological activities.The mechanism is clear. It has a good future prospect for the application of traditional Chinese medicine in bone tissueengineering.