胰岛素样生长因子结合蛋白3在疾病诊断与风险评估中的潜在价值

摘要

BACKGROUND:Insulin-like growth factor 1 (IGF1) plays an important role in cellgrowth, proliferation and differentiation. Insulin-like growth factor binding protein 3 (IGFBP-3), as the main binding protein of IGF1, is involved in the regulation of IGF1. OBJECTIVE:To attempt to analyze the relation of IGFBP-3 and various diseases, and to explore the potential values of IGFBP-3 in disease diagnosis and risk assessment. METHODDatabases of PubMed, Science Direct and Wanfang database were retrieved with key words of“insulin-like growth factors 1;IGFBP-3;cancer;growth hormone deficiency;diabetes;osteoporosis”in English and Chinese, respectively, by screening titles and abstracts to search papers related to IGFBP-3 structure and function as wel as relationship of IGFBP-3 with cancer, growth hormone deficiency, diabetes, osteoporosis. Final y, 43 articles were summarized according to inclusion criteria. RESULTS AND CONCLUSION:In recent years, the relationship between gene of IGFBP-3 and risk of cancer is becoming a hot research topic. The results show that IGFBP-3 is a protective agent of cancer risk, and it is an important factor in evaluating the risk of cancer, exhibiting a potential application value. IGFBP-3 is also associated with growth hormone deficiency and diabetes. In addition, IGFBP-3 can assist IGF-1 to play the regulatory role in bone growth and differentiation, which is closely linked with osteoporosis. Therefore, IGFBP-3 can be a potential predictor for osteoporosis.%背景：胰岛素样生长因子1在细胞的生长、增殖与分化等方面发挥了重要作用，而IGFBP-3作为胰岛素样生长因子1的主要结合蛋白，参与了对胰岛素样生长因子1生理功能的调控。　　目的：试图分析胰岛素样生长因子结合蛋白3与多种疾病的关系，探索胰岛素样生长因子结合蛋白3在这些疾病诊断与风险评估中的潜在应用价值。　　方法：以“insulin-like growth factors 1；IGFBP-3；cancer；growth hormone deficiency；diabetes；osteoporosis”为检索词检索PubMed数据库、英文数据库及万方医学网。收集与胰岛素样生长因子结合蛋白3结构及功能相关的文献，以及胰岛素样生长因子结合蛋白3与癌症、生长激素缺乏症、糖尿病及骨质疏松相关的文献，最后选择43篇进行归纳总结。　　结果与结论：近年来，胰岛素样生长因子结合蛋白3的基因与癌症风险的相关性研究正逐渐成为一个研究热点。结果表明，胰岛素样生长因子结合蛋白3是一种癌症风险的保护剂，是评估癌症风险的重要因子，具有潜在的应用价值。胰岛素样生长因子结合蛋白3还与生长激素缺乏症、糖尿病相关，并可与胰岛素样生长因子1协同作用对骨的生长分化发挥调控作用，与骨质疏松有着紧密的联系，可作为一种预测骨质疏松的潜在指标。