基于石墨烯构筑的三维组织工程支架材料

摘要

背景：基于石墨烯纳米片的化学成分和物理结构，可形成与细胞外生物基质十分相似的微观环境。目的：综述近年来基于石墨烯构筑三维支架的制备、细胞相容性及与细胞的相互作用。方法：应用计算机检索中国知网CNKI数据库、ACS-ACS Publications、Elsevier Science, Nature及PNAS美国国家科学院院刊等，有关生物医用石墨烯材料的种类和制备方法及其在组织工程中的应用研究。结果与结论：将石墨烯及其衍生物作为模块，利用石墨烯二维平面结构特点或氧化石墨烯含有丰富的官能团特性，不仅能够将石墨烯纳米片以不同的方式组装构筑三维宏观结构，而且易于复合其他功能性材料。与单个石墨烯片或传统的碳纳米材料相比，三维宏观石墨烯及复合材料将有可能形成更为新奇独特的结构及性能，具有更加实际的应用价值，包括拥有组织工程支架的功能。%BACKGROUND:Based on the chemical composition and physical structure, graphene nanosheets can be used to form a very similar biological micro-environment to the extracelular matrix. OBJECTIVE:To review the preparation, cytocompatibility and cel interaction of graphene-based three-dimensional scaffolds in recent years. METHODS:A computer-based search of CNKI, ACS-ACS Publications, Elsevier Science, Nature and PNAS was performed to retrieve articles related to the type, preparation and application of biomedical graphene in tissue engineering. RESULTS AND CONCLUSION:Graphene and its derivatives are made as a module, and based on its two-dimensional structural characteristics or functional groups enriched in oxidized graphene, graphene nanosheets can be assembled in different ways to build a three-dimensional macroscopic structure that is easy to compound other functional materials. Compared with a single graphene sheet or carbon nanomaterials, three-dimensional macroscopic graphene and its composite materials wil be more likely to form new and unique structures and properties, which have more practical values and possess the functions of tissue engineering scaffolds.