盐负荷对自发性高血压模型大鼠胸主动脉应力松弛特性的影响

摘要

BACKGROUND:In recent years, great progress has been achieved in the mechanical and viscoelastic properties of arterial blood vessels of normal human corpses and animals. OBJECTIVE: To quantitatively analyze the tensile mechanical properties of thoracic aorta in normaly fed spontaneously hypertensive rats and salt-loaded spontaneously hypertensive rats. METHODS: Twenty spontaneously hypertensive rats were obtained and randomly divided into experimental and control groups (n=10/group). Rats in the experimental group were subjected to continuous salt loading intervention for 16 weeks. Rats in the control group were fed with normal diet and ordinary tap water. At the 16th week, 10 specimens of thoracic aorta of rats from these two groups were harvested to conduct stress relaxation experiments.RESULTS AND CONCLUSION: The decrease in stress at 7 200 seconds and the decrease in normalized stress relaxation function value at 7 200 seconds of thoracic aortic specimens of rats in experimental group were both lower than those in the control group (P< 0.05). These results confirm that the stress relaxation properties of thoracic aorta of normaly fed and salt-loaded spontaneously hypertensive rats change, wherein the changes in salt-loaded spontaneously hypertensive rats are more obvious.%背景：近年来正常人尸体和动物动脉血管的力学特性和黏弹性研究取得了一定的成果。目的：定量分析正常饲养自发性高血压大鼠和盐负荷自发性高血压大鼠胸主动脉拉伸力学特性。方法：取20只自发性高血压大鼠，随机分为实验组和对照组各10只，对实验组大鼠持续盐负荷干预16周，对照组大鼠引用普通自来水，正常饮食。实验第16周，取两组大鼠胸主动脉各10个试样进行应力松弛实验。结果与结论：实验组大鼠胸主动脉试样7200 s应力下降量、7200 s归一化应力松弛函数下降值均低于对照组(P <0.05)。结果证实，自发性高血压大鼠和盐负荷自发性高血压大鼠胸主动脉应力松弛特性均发生了改变，其中盐负荷自发性高血压大鼠变化较显著。