BACKGROUND: Glucocorticoids play an essential role in osteoblast differentiation, but excessive glucocorticoids will inhibit the osteoblastic phenotype. Regulation of 11β-hydroxysteroid dehydrogenase (11β-HSD) contributes to optimizing the effect of glucocorticoids.OBJECTIVE: To summarize the effect of 11β-HSD in bone metabolism.METHODS: The corresponding author retrieved PubMed and CJFD databases for the articles published before 2016 using the keywords "11β-HSD, bone" in English and Chinese, respectively. Totally 115 articles were retrieved, including 98 English and 17 Chinese articles, and finally 45 eligible articles were included in accordance with the inclusion criteria.RESULTS AND CONCLUSION: Glucocorticoid action can be regulated at prereceptor level by 11β-HSD. 11β-HSD1 activity may predict individual susceptibility to glucocorticoids, which instructs the individualized application of glucocorticoids precisely. 11β-HSD1 activity is closely related to osteoblast differentiation and the presence of an intrinsic differentiation-driven molecular switch inhibits the activity of 11β-HSD1. Instead of regulating the mesenchymal progenitors directly, gucocorticoids regulate the mesenchymal progenitors to differentiate into cranial skeleton mainly through mature osteoblasts. Short-term glucocorticoid exposure directly increases 11β-HSD1 activity and continuous exposure to glucocorticiod indirectly inhibits 11β-HSD1 activity.%背景:糖皮质激素既是成骨细胞分化所必需,但过量又会抑制成熟成骨细胞的表型,11β-羟基类固醇脱氢酶可以调控糖皮质激素的活性,使糖皮质激素的利用结果最优化.目的:综述11β-羟基类固醇脱氢酶在骨代谢过程中发挥的作用.方法:由通讯作者检索至2016年的PubMed数据库、 中国期刊全文数据库的相关文章,英文关键词为"11β-HSD,Bone",中文检索词为"11β-羟基类固醇脱氢酶,骨".找到英文文献98篇,中文文献17篇,检索文献量总计115篇.共保留45篇做进一步分析.结果与结论:①11β-羟基类固醇脱氢酶对糖皮质激素的活性有重要的受体前水平调节作用;②11β-羟基类固醇脱氢酶的活性可以预测个体骨代谢受糖皮质激素影响的敏感度,可以根据个体差异性精准使用糖皮质激素的用量;③11β-羟基类固醇脱氢酶的活性与成骨细胞的分化活跃度密切相关,分化活跃的成骨细胞可以抑制自身11β-羟基类固醇脱氢酶的活;④糖皮质激素促进小鼠颅骨发育,并不是直接影响间叶细胞,而是通过影响成熟成骨细胞再间接作用于间叶细胞;⑤短期应用糖皮质激素可以直接促进11β-羟基类固醇脱氢酶的表达,而长期应用糖皮质激素可以间接抑制11β-羟基类固醇脱氢酶的表达.
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