干细胞移植治疗炎症性肠病

摘要

背景:理论上,干细胞可以重建并调节人体免疫系统,而且干细胞具备定向分化功能,从而有望用于治疗炎症性肠病.目的:综述不同类型干细胞干预炎症性肠病的研究进展.方法:以"干细胞,造血干细胞,间充质干细胞,炎症性肠病,克罗恩病,溃疡性结肠炎"为中文检索词,以"stem cels transplantation,cel therapy,inflammatory bowel diseases,ulcerative colitis,Crohn's disease"为英文检索词,在中国知网(CNKI)期刊全文数据库、PubMed数据库以及FMJS数据库检索2002年1月至今有关干细胞移植治疗炎症性肠病的文献.最终纳入49篇文献进行综述.结果与结论:胚胎干细胞与成体干细胞对炎症性肠病均有一定的治疗作用,但具体哪一种类型的干细胞最安全、最有效以及此种细胞的最佳剂量与移植途径等,仍需要开展大量的研究.%BACKGROUND:Stem cell transplantation can, in theory, rebuild the immune system and regulate immunologic function. In addition, the transplanted stem cells may differentiate into tissues or cells we want. Therefore, this intervention may restore gastrointestinal inflammatory lesion and exert therapeutic effect on inflammatory bowel diseases (IBD). OBJECTIVE:To review the application of different kinds of stem cells in IBD treatment. METHODS:A computer-based search of CNKI, PubMed and FMJS was performed for articles concerning stem cel transplantation and IBD published after January 2002. The key words were "stem cells, inflammatory bowel diseases, Crohn's diseases, ulcerative colitis, cell therapy" in Chinese and English respectively. At last, 49 articles were included in result analysis. RESULTS AND CONCLUSION: Embryonic stem cells and adult stem cells both have certain therapeutic benefits in IBD. But which kind of stem cell is the safest and most efficacious cannot be confirmed, and at the same time the most effective and the optimal dose and way of transplantation of such cells are still unclear. All in all, there is still a lot of work to do to remove the obstacles.