毁损伏隔核、腹侧苍白球对大鼠觅药行为的影响

摘要

Objective To study the reinforcing effect of the nucleus accumbens and ventral pallidum in rats.Method Electrolytic lesions of the nucleus accumbens and ventral pallidum was done separately in 20 rats amd hbejavopr was ,easired by conditioned place preference paradigm in rats.Result Electrolytic lesions of the nucleus accumbens showed an extinction of the place－ preference for morphine－ paired environment in rats and ventral pallidum lesions significantly decreased the place－ preference.Conclusion The nucleus accumbens and ventral pallidum are important sites mediating the reinforcing effects of morphine and the nucleus accumbens－ ventral pallidum circuit is a common pathway for opiate reinforcement.%目的探讨伏隔核和腹侧苍白球在药物强化中的作用。方法分别毁损成瘾大鼠伏隔核、腹侧苍白球，利用条件性地点偏好实验测定术前、术后成瘾大鼠对注射吗啡的偏好分，评价伏隔核和腹侧苍白球在药物强化效应的作用。结果毁损大鼠双侧伏隔核能够完全消除大鼠对注射吗啡侧的偏好，毁损腹侧苍白球明显减少成瘾大鼠的地点偏好行为。结论伏隔核和腹侧苍白球是调节强化作用的重要位置，伏隔核－腹侧苍白球通路是药物强化的共同环路。