中国南方冠心病介入治疗患者 CYP2 C19基因多态性分析

摘要

目的：研究中国南方冠心病介入治疗患者CYP2C19基因多态性的分布。方法选取确诊为冠心病并同意行冠状动脉支架术（ PCI）治疗的患者112例，抽取外周血并通过提取基因组DNA检测CYP2C19的基因型。结果在112例检测标本中，CYP2C19纯合子强代谢型（homEMs）、杂合子强代谢型（hetEMs）及弱代谢型（PMs）的发生率分别为40.2％、48.2％和11.6％。结论中国南方冠心病介入治疗患者中，弱代谢者的发生率低于中国汉族人总体发生率。%Objective To investigate distribution status of cytochrome CYP 2C19 polymorphisms in Southern Chinese patients with coronary disease undergoing percutaneous coronary intervention ( PCI ).Methods We selected 112 patients who were diagnosed as coronary heart disease and agreed to receive PCI treatment, took patients’peripheral blood and extracted genomic DNA to determine the CYP 2C19 geno-type.Results The frequency of CYP2C19 homozygous extensive metabolisms ( homEMs),heterozygous ex-tensive metabolisms(hetEMs)and poor metabolisms(PMs)in the 112 cases with coronary disease undergoing PCI was respectively 40.2%、48.2%and11.6%.Conclusion In Southern Chinese patients with PCI , the frequency of CYP2C19 poor metabolisms is lower than its frequency of Chinese population.