降钙素原、超敏C-反应蛋白和纤维蛋白原在糖尿病足感染患者中的变化

摘要

Objective To investigate the expression changes and their relationship among procalcitonin(PCT),high-sensitivity C reactive Protein (hs-CRP),and fibrinogen(Fbg) in patients with the diabetic foot(DF)infections. Methods A total of 55 DF patients in our hospital from November 2015 to October 2016 were selected as study subjects,and divided into the infected group(29 cases) and non-infection group(26 cases),depending on whether the presence of foot-infections,while 26 cases with diabetes unincorporated DFI were selected as the control group. PCT,hs-CRP and Fbg levels were detected by immune-fluorescence, immunoturbidimetry and plasma coagulation,respectively. Results PCT,hs-CRP and Fbg levels in the infected group were significantly higher than those in the control group(P < 0. 01); PCT and Fbg levels in the infected group were significantly higher than those in the non-infection group(P < 0. 01); hs-CRP levels in the infected group were higher than those in the non-infection group(P < 0. 05); PCT,hs-CRP and Fbg levels in the non-infection group were higher than those in the control group(P < 0. 05). By correlation analysis,PCT and Fbg in the infected group had significantly correlated with the non-infection group(r = 0. 751,P < 0. 01), and hs-CRP and Fbg in the infected group had significantly correlated with the non-infection group (r = 0. 383,P < 0. 01)too. Conclusion Patients with DFI should detect PCT,hs-CRP and Fbg levels to carry out early anti-infective and anticoagulant therapy.%目的 探讨糖尿病足感染(DFI)患者血清降钙素原(PCT) 及血浆超敏C-反应蛋白 (hs-CRP)、纤维蛋白原(Fbg)的水平变化及临床意义.方法 选取2015年11月～ 2016年10月本院内分泌科收治的糖尿病足(DF) 患者55例,依据是否存在足部感染分为糖尿病足合并感染组(29例)和糖尿病足未合并感染组(26例),同时选取26例患有糖尿病但未合并DF患者为对照组.采用荧光定量法检测患者血清PCT水平,采用免疫比浊法检测患者血浆hs-CRP水平,采用凝固法检测患者血浆Fbg水平.结果DFI组患者的PCT、hs-CRP及Fbg水平显著高于对照组(P < 0. 01); DFI组患者的PCT和Fbg水平显著高于DF未合并感染组,差异有统计学意义(P < 0. 01); DFI组患者的hs-CRP水平显著高于未合并感染组,差异有统计学意义(P < 0. 05); DF未合并感染组患者的PCT、hs-CRP和Fbg水平显著高于对照组,差异有统计学意义(P < 0. 05).经相关性分析,感染组患者PCT与Fbg水平与未合并感染组患者呈显著正相关 (r = 0. 751,P < 0. 01),hs-CRP与Fbg水平与未合并感染组患者也呈显著正相关(r = 0. 383,P < 0. 01).结论 糖尿病患者无论是否存在糖尿病足均应积极检测血清PCT、血浆hs-CRP和Fbg水平,并早期进行抗感染及抗凝治疗,以保障周围血管血供.