2-取代-3-N-酰基-5-氟-4-嘧啶酮的合成及其抗肿瘤活性

摘要

Fourteen new 2-substituted-3-acyl-5-fluoro-4-pyrimidone compounds were prepared by the reaction of 2-substituted-5-fluoro-3H-4-pyrimidones with acyl chlorides in acetone in the presence of Et3N. Their structures were confirmed by IR, 1H NMR and elementary analysis or MS. The preliminary antitumor tests showed that some of them exhibited certain activities.%在丙酮溶液中,于Et3N存在下使2-取代-5-氟-4-嘧啶酮与酰氯反应,合成了14个未见文献报道的2-取代-3-N-酰基-5-氟-4-嘧啶酮类化合物,它们的结构经IR,1H NMR,元素分析或MS确定.其中有些化合物具有一定的抗肿瘤活性.