合成3-苯甲酰胺基-6-甲基-2-吡喃酮衍生物的新方法

摘要

Two 3-benzoylamino-6-methylpyran-2-one derivatives and a new compound, 3-benzoylamino-5-(1-hydroxyehtyl)-6-methyl-pyran-2-one, were synthesized from hippuric acid, ethyl orthoformate, ethyl acetoacetate or acetyl acetone. The total yield were 66% and 42%, respectively. The structures were characterized by 1H NMR and 13C NMR.%以马尿酸、原甲酸三乙酯和乙酰乙酸乙酯或乙酰丙酮为原料,合成了两个3-苯甲酰胺基-6-甲基-2-吡喃酮衍生物(总产率66％)和一个新化合物——3-苯甲酰胺基-5-羟乙基-6-甲基-2-吡喃酮(总产率42％),其结构经1H NMR和13C NMR表征.