(+)-(1S,7aS)-1-羟基-7a-甲基-茚满-4-烯-5-酮的合成及其烷基化反应研究

摘要

( + )-(lS,7aS)-l-hydroxy-7a-methyl-l, 2, 3, 6,7, 7a-hexahydro-inden-5-one (3) was synthesized by cyclization and reduction reaction from 2-methyl-2-(3-oxobuty) cyclopentane-1,3-di-one. Five derivatives of 3 were prepared by a-alkylation of 3 with side chains of aromatic ring in the case of the hydroxyl of 3 non-protected. The structures were confirmed by ' H NMR.%以2-甲基-2-(3-丁酮)环戊烷-1,3-二酮为原料,经环合和还原反应合成了手性(+)-(1S,7aS)-1-羟基-7a-甲基-茚满-4-烯-5-酮(3)；3在其羟基未进行保护情况下与不同芳香侧链进行α,β-不饱和酮的α-位烷基化反应,制备了5个3的衍生物,其结构经1H NMR确证.