合成2,3,4,6-O-四苄基-α-D-葡萄糖三氯乙酰亚胺酯的工艺改进

摘要

2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl trichloroacetimidate in total yield of 44.2％ was synthesized from D-glucose by methylation,benzyl protection,hydrolysis and then reaction with trichloroacetonitril.The structures were confirmed by 1 H NMR and ESI-MS.%以D-葡萄糖为起始原料,经甲基化、苄基保护和水解,再与三氯乙腈反应合成了2,3,4,6-O-四苄基-α-D-葡萄糖三氯乙酰亚胺酯,总收率44.2％,其结构经1H NMR和ESI-MS确证.