1,3,4,6-四-O-苄基-β-D-氨基葡萄糖盐酸盐的合成方法改进

摘要

1,3,4,6-Tetra-O- benzyl-β-D-glucosamine schiff base (2) was synthesized from D-glu-cosamine hydrochloride. 1,3,4,6-tetra-O- benzyl-β-D-glucosamine hydrochloride was synthesized by the reation of 2 and benzyl bromide in dry DMF. The structure was confirmed by 1H NMR and IR.%以D-氨基葡萄糖盐酸盐为原料,制得D-氨基葡萄糖希夫碱(1)；在无水DMF溶液中,1与苄溴反应得1,3,4,6-四-O-苄基-β-D-氨基葡萄糖希夫碱(2)；2经酸解,甲醇/水重结晶合成了高纯度的1,3,4,6-四-O-苄基-β-D-氨基葡萄糖盐酸盐,其结构经1 H NMR和IR确证.