三氟甲磺酸铁催化新型1,3,5-三苯基苯类化合物的合成

摘要

以苯乙酮类化合物为原料,三氟甲磺酸铁[Fe(OTf)3]为催化剂,经自身三聚缩合反应合成了18个1,3,5-三苯基苯类化合物(2a~2r),其中2o~2r为新化合物,其结构经1H NMR,13C NMR和HR-MS(ESI)表征.研究了催化剂种类及其用量、溶剂、温度和反应时间对2a产率的影响.结果表明:在最佳反应条件[Fe(OTf)30.02 eq.,甲苯为溶剂,于100℃反应4 h]下,2a产率91%.%Eighteen 1,3,5-triarylbenzenes (2a~2r, 2o~2r were novel compounds) were synthesized by cyclotrimerization of acetophenone derivatives, using Fe( OTf) 3 as the catalyst.The structures were characterized by 1 H NMR, 13 C NMR and HR-MS( ESI) .The effects of catalysts and its amount, sol-vent, reaction temperature and reaction time on the yield of 2a were investigated.The results showed that 2a achieved the highest yield(91%) under the optimum reaction conditions[Fe(OTf)30.02 eq., toluene as solvent, reaction at 100 ℃ for 4 h] .