胃旁路术后GK大鼠的铁代谢及血糖改变

摘要

目的：观察胃旁路术后2型糖尿病GK大鼠血清铁、铁蛋白、总铁结合力及血糖的改变。方法：将30只12周龄的雄性GK大鼠随机分为手术组、假手术饮食控制组及假手术空白对照组各10只，观察手术前后铁代谢、血糖、进食量和体重变化，并于术前和术后第4、8周行口服糖耐量实验。结果：术后8周，胃旁路术组空腹血糖较术前明显下降（P＜0.01），糖耐量曲线下面积、血清铁和铁蛋白均明显降低（P＜0.01），总铁结合力明显上升（P＜0.01）。结论：2型糖尿病大鼠胃旁路术后血糖改善，血清铁、和铁蛋白显著下降，总铁结合力升高。%weight were recorded before and after surgery. The serum iron, serum ferritin and total iron binding capacity were determined before surgery and 4 weeks and 8 weeks after operation. Results In Group O,serum parame-ters before and 8 weeks after surgery were as follows:Serum glucose (17.6±2.1vs,8.2±1.1, P<0.01), SI(215.18± 36.55 vs 86.65±26.61, P<0.01),SF(1.076±0.273 vs 0.768±0.178,P<0.01),and TIBC(455.40±81.96 vs 643.11± 58.77,P<0.01) In Group B and C,the parameters levels of iron metabolism were not different. Conclusion Gastric bypass surgery reduces serum iron concentration in type-2 diabetic rats and this effect may be involved in the improvement of blood glucose seen in the same rats.