Synthesis and Crystal Structure of (2S,5S)-1-Aza-2-(2-pyridyl)-3-oxa-4,4-diphenylbicyclo 3.3.0 Octane

摘要

The title compound (C23H22N2O) 3 has been synthesized by the reaction of (S)(-)-1,1-diphenyl-2-pyrrolidinemethanol 1 with 2-pyridinecarboxaldehyde 2 in refluxing benzene catalyzed by TsOH, and its structure was determined by single-crystal X-ray diffraction. The crystal belongs to orthorhombic, space group P212121 with a = 8.4747(8), b = 10.8829(10), c = 19.777(2) A,Mr = 342.43, V =1824.0(3)A3, Dc = 1.247 g/cm3, Z = 4,μ = 0.077 mm-1 and F(000) = 728. The structure was solved by direct methods and refined by full-matrix least-squares techniques to the final R = 0.0497 and wR = 0.0927.