(1aR, 5S, 15s, 10R, 22ar) - 5 - Tert Butyl N - ((1R, 2S) - 1 - (cyclopropylsulfonyl) amino carbonyl vinilciclopropil}} - 2 - methoxy - 14 - 3.6 - - 1, 1, 3, 4, 5, 6 9, 10, 18, 19, 20, 21, 22, 22a - tetradecahidro - 8h - 7, 10 - metanociclopropa 18, 19 1, 10, 3, 6 dioxadiazaciclononadecino 11, 12 quinoxalin - B - 8 - carb Oxamida as HCV NS3 protease inhibitor

摘要

Refers to a compound of formula (i macrociclico quinoxaline) (1aR, 5S, 15s, 10R, 22ar 5) - Tert Butyl N - ((1R, 2S) - 1 - [(cyclopropylsulfonyl) amino] carbonyl] - 2 - vinilciclopropil) - 6 - methoxy - 3.6 [- - - - 3,4,5,6,9,10,18,19,20,21,22,22a 1,1a, tetradecahidro 8h - metanociclopropa [18,19] [7,10] diox 1,10,3,6 Adiazaciclononadecino [11,12] quinoxaline - B - 8 - carboxamide.It also relates to a Pharmaceutical composition comprising a Second Therapeutic Agent as a protease inhibitor of hepatitis C virus (HCV) and HCV NS5b polymerase inhibitor. This Compound is an inhibitor of the NS3 protease of hepatitis C virus (HCV) is useful in the treatment of hepatitis C