A 6,(17)-epoxylathyrol diterpenoid ((2S*3S*4R*5R*6S*9S*11S*15R*)-5,15-diacetoxy-3- phenylacetoxy-14-oxolathyra-6(17),(12E)-diene-6(17)-epoxide) was isolated from the seeds of Euhporbia lathyris L. Its configuration was puzzled because of the incomplete X-ray results reported before. In this work, the atom connectivity and configuration were confirmed by single-crystal X-ray diffraction together with ESI-MS, 1H-, and 13C-NMR spectroscopy. The compound crystallizes in monoclinic, space group P21 with a = 11.386(1), b = 8.2839(7), c = 17.192(2)(A), β = 108.305(2)o, Z = 2, V = 1539.5(2)(A)3, C32H40O8, Mr = 552.64, Dc = 1.192 g/m3, F(000) = 592, μ(MoKα) = 0.085 mm-1, T = 293(2) K, the final R = 0.0398 and wR = 0.0950 for 2057 observed reflections with I > 2σ(I). The molecule shows a tricyclic terpenoid skeleton, consisting of fused five-, eleven- and three-membered rings. The configuration at C(5) is R* and that at C(6) S*.
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