Synthesis, Crystal Structure and Antibacterial Activity of 4,4'-Hydrazine-1,2-diylidenebis(methanylylidene)bis(2-ethoxyphenol)

摘要

A new Schiff base compound, 4,4'-hydrazine-1,2-diylidenebis(methanylylidene)-bis(2-ethoxyphenol) (C18H20N2O4), has been synthesized by the condensation of 3-ethoxy-4-hydroxybenzaldehyde and 80% hydrazine hydrate in an ethanol solution. The compound was characterized by 1H NMR, MS and single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group P21/n with a = 5.2421(5), b = 10.3700(8), c = 14.9906(11) , β = 97.6030(10)°, Z = 2, V = 807.73(12) , Dc = 1.350 g/cm3, Mr = 328.36, λ(MoKα) = 0.71073, μ = 0.096 mm-1, F(000) = 348, R = 0.041 and wR = 0.0136. The two benzene rings are coplanar. The molecule adopts an E,E configuration about the central C=N functional bonds. A total of 3938 unique reflections were collected, of which 1440 with I > 2σ(I) were observed. A different type of intermolecular hydrogen bond, O-H···N, exists in the crystal. The title complex molecules are connected through hydrogen bonds to generate a two-dimensional network. The preliminary antibacterial activity results showed that the title compound exhibits antibacterial activity against Staphylococcus aureus.