内皮祖细胞治疗缺血性脑血管病的研究进展

摘要

内皮祖细胞（endothelial progenitor cel，EPC）可促进缺血损伤后脑组织血管新生及神经发生。近年来，移植外源性EPC、动员内源性EPC等治疗方法在缺血性脑血管病的实验研究中开辟了新的途径，并证实EPC在外周血中的水平对缺血性脑血管病的严重性及预后具有预测价值。本文对EPC治疗缺血性脑血管病的作用机制，治疗策略，在临床应用中尚存在的问题，以及最新研究进展做一综述。%Endothelial progenitor cell (EPC) can promote the angiogenesis and the neurogenesis in the cerebral ischemic injury. In recent years, the therapeutic strategy such as transplanting EPC or mobilizing EPC opens a new avenue in the experimental research, and it has demonstrated that the level of EPC in the peripheral blood has a predictive value in the severity and prognosis of ischemic cerebrovascular disease. In this article, we make a review of the mechanism of EPC in the treatment, the therapeutic strategy, the existing problems in the clinical application, as well as the advances in the latest research.