MiRNA与血小板活性的研究进展：一个新的评估抗血小板治疗效果的潜在生物标志物

摘要

微RNA（microRNA，miRNA）是一种非编码的小RNA分子，在人体内含量丰富且参与许多生命活动的调控。MiRNA在血小板形成、mRNA调控、蛋白合成及激活各个过程均有特异性表达，如miRNA参与调节巨核细胞的生成、分化和血小板激活通路等。许多研究试图进一步阐明miRNA与血小板活性的关系，为寻找评估抗血小板治疗效果的生物标志物提供了新的方向。%MicroRNA (miRNA) is a non-coding small RNA molecule, participating in regulating biologic activities, with a large quantity. MiRNAs have their specific expression in different processes related to platelet formation, mRNA regulation, protein synthesis and platelet activation. For instance, miRNA participates in regulating the biogenesis and differentiation of megakaryocytes and the pathway of platelet activation. Scientists pay a lot of efforts to ifgure out the relationship between miRNA and platelet reactivity, which points out a new possibility to evaluate the efifcacy of anti-platelet therapy by using miRNA as a novel biomarker. This article is trying to review the studies about the relevance between miRNA and platelet reactivity.