非致残性缺血性脑血管病生物标记物研究进展

摘要

Transient ischemic attack (TIA), minor ischemic stroke and rapid remission of ischemic cerebrovascular events collectively are defined as non-disabling ischemic cerebrovascular events (NICE), with a high risk of recurrence of early stroke, which need serious and urgent interventions. However, there are no well-known biomarkers with high value in predicting prognosis after NICE. The researches focus on NICE biomarkers to predict outcome rapidly and accurately has become a hotspot. This review is to provide introduction about biomarkers of NICE from aspects of thrombosis factors, inflammatory factors, metabonomics abnormalities and gene, etc.%短暂性脑缺血发作、轻型卒中和症状迅速缓解未遗留残疾的缺血性脑血管事件统称为非致残性缺血性脑血管事件(non-disabling ischemic cerebrovascular events,NICE),具有早期卒中复发风险高的特点,是严重的、需要紧急干预的事件.至今尚无公认的对NICE预后预测价值高的生物标记物.寻找快速准确的NICE预后的生物学标记物成为目前研究的热点,本文将就血栓形成因子、炎症因子、代谢异常、基因学等对NICE预后的预测价值进行阐述.