脑白质高信号对急性缺血性卒中患者功能恢复的影响的研究进展

摘要

脑白质病变是脑小血管病在磁共振成像T2加权像中检测到的影像学表现,表现为白质高信号(white matter hyperintensity,WMH),是增加急性缺血性卒中风险和严重程度的重要因素.研究表明WMH负荷不仅与缺血性卒中的风险和功能结局有关,在认知功能障碍和痴呆的风险中也发挥了重要的作用.本文将阐述目前关于WMH的神经病理学及其负荷对急性缺血性卒中后功能恢复的影响的最新研究.%Cerebral white matter lesion is the imaging finding of small vascular disease detected on T2-weighted brain magnetic resonance imaging (MRI) and manifested with white matter high signal, which is the key factor for causing the risk and the severity of acute ischemic stroke (AIS). Studies have shown that white matter hyperintensity (WMH) burden was not only related to the risk of ischemic stroke and functional outcomes, but also played an important role in cognitive impairment and dementia. This paper is to discuss the research progress in the neuropathology of WMH and the impact of its burden on AIS and functional recovery.