诱导性生物材料与牙周组织再生

摘要

Periodontal regeneration is a great challenge faced by clinical treatment, and traditional therapies are not effective in regenerating periodontal tissues. Bioinductive biomaterials are materials that are able to induce the regeneration of damaged tissues, and they can induce the migration of stem cells or precursor cells to the defect site to proliferate, differentiate for tissue regeneration. For example, the osteoinductive biomaterials are able to induce regeneration of alveolar bone. In this review, the writer combined the recent advances of both clinical and scientific field, and summarize the application of bioinductive biomaterials includingautogenous bone, human derived growth factors, enamel matrix proteins and platelet-rich fibrin.%牙周再生是临床牙周治疗中的一大挑战,使用传统治疗方法难以实现良好的牙周再生.诱导性生物材料是指能诱导组织再生的生物活性材料,此类材料可诱导机体内的干细胞或再生所需的前体细胞迁移到组织缺损部位,进而增殖、分化,达到组织再生的目的 ,如骨诱导材料可诱导牙槽骨等骨组织再生.本文将结合现有的临床研究与笔者最新的研究,从自体骨、人源性生长因子、釉基质蛋白、富血小板纤维蛋白、靶向性骨诱导材料5个方面阐述诱导性生物材料在牙周再生中的应用.