智能释药胶囊内酸碱度测量模块的设计

摘要

A smart capsule for drug delivery based on a pH sensor was proposed here. The system can automatically identify the pH changes of the gastrointestinal (GI) tract, and then it can automatically release the drug if the pH changes satisfy the established procedure. A pH measuring module in this system was designed here. The pH measuring module consists of pH sensor module, measuring circuit module, microprocessor chip module, and power management module. The performances of pH measuring module and pH sensors were tested in vitro experiments. The experimental results showed that the sensitivity of pH sensor was 43.5 mV/pH, which met the need of pH measuring in the GI tract. Additionally,when the trigger voltage stored in the micro controller unit( MCU)was from 113.1 to 282.8 mV, the capsule could release the medicine in the esophagus, stomach and intestinal tract accurately according to the change of pH value.%提出了一种能够根据消化道中pH值的变化而自动释药的智能释药电子胶囊,设计了基于pH传感器的酸碱度测量模块.酸碱度测量模块包括pH传感器模块、测量电路模块、微处理器芯片模块和电源管理模块.在离体状态下对pH传感器进行了原理性实验,并对酸碱度模块的性能进行了测试.实验结果表明pH传感器的灵敏度为43.5 mV/pH,满足消化道内pH值测量的需要,得出单片机程序中的触发电压范围为113.1～282.8 mV,通过pH值变化的测定,可以准确的在食道,胃部,和肠部三个区域内进行释药.