目的：研究健康孕妇妊娠晚期血清唾液酸及新生儿脐血血清唾液酸之间的相关性，探讨唾液酸胎盘转运率对胎儿唾液酸的影响，为评价健康母胎之间唾液酸转运能力提供参考。方法采集100名健康孕妇妊娠晚期空腹静脉血及分娩时胎儿脐静脉血，使用高效液相色谱法测定血清中的唾液酸浓度。结果妊娠晚期血清唾液酸与新生儿脐血清唾液酸含量正相关（r ＝0．243），唾液酸胎盘转运率波动范围为0．16～0．76。结论母婴唾液酸正相关可能是母体对胎儿逐渐增加的唾液酸需求的反应；脐带血唾液酸水平相对孕母血唾液酸，波动范围更窄，变化更小，推测唾液酸胎盘转运能力反映了孕妇血清唾液酸通过胎盘的能力。%Objective To investigate the correlation of serum sialic acid (SA)concentration of healthy pregnant women at third trimester and SA concentration in neonatal umbilical cord serum. Methods Blood samples were collected from 100 pregnant women at the third trimester,and the fetal umbilical venous blood samples were collected at delivery. Serum SA concentrations were measured with high performance liquid chromatography method. Results Serum SA concentration in pregnant women showed positive correlation (r =0.243)with umbilical cord SA.The placental transfer rates ranged from 0.16 to 0.76. Conclusion The consistency of maternal﹣fetal blood serum sialic acid reflected the self adjusting function between maternal SA and fetal SA.We speculated the placenta transfer rate of SA was the index of dynamic balance between mother and womb.
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