核磁共振检测活体兔心肌梗死体积的实验研究

摘要

目的:探讨3.0T核磁共振(Magnetic resonance imaging,MRI)活体检测兔心肌梗死的体积,以利于后续生理机能的观察.方法:10只成年雄性新西兰白兔被制作成心肌梗死模型后,先用MRI进行活体心肌梗死体积检测；而后处死,再用TTC染色法测量其心肌梗死体积.结果:MRI测量的心肌梗死体积显著高于TTC染色法(30.09％±2.45％与25.93％±2.22％,P＜0.01),且两者有显著相关性(r=0.974,P＜0.01).结论:3.0 T MRI可用于小动物心肌梗死体积的活体测量,可作为心肌梗死后其他研究指标的观察.%Objective: To study the applied value of magnetic resonance imaging (MRI) in measuring infarct size of myocardium in rabbits. Methods: The myocardial infarction models in 10 male adult New Zealand white rabbits were established. After MRI examination, rabbits were sacrificed and left ventricles of their hearts were stained by TTC to calculate infarct size again. Results: The infarct size measured by MRI was significantly larger than that by TTC staining (P<0. 01) and the two methods had a great relationship. Conclusion; MRI can measure infarct size of rabbits in vivo.