Objective To observe the role of working memory in the process of language, and provide an objective evaluation for Chinese language rehabilitation.Methods From December, 2017 to June, 2018, 20 healthy subjects accepted word-picture matching tasks as the word and picture showed on the different (task 1) or same (task 2) screens, and their event-related potential of N400 were compared in matched and mismatched conditions.Results Forteen subjects were included finally. Task 1 induced N400 appeared earlier with higher amplitude and more activation in central parietal occipital region, followed larger N170 and P1 wave. There were significant differences in most cerebral regions between the two tasks in N400 amplitude difference of matched and mismatched conditions (t＞ 2.319, P ＜ 0.05).Conclusion Word-picture matching tasks may involve more language-related brain regions with the intervention of working memory, that might work better in process of vocabulary. The tasks simulating the scene of Chinese language rehabilitation can be used as an objective evaluation for clinical activities.%目的 探究工作记忆在语言康复训练中的作用,为汉语语言康复提供客观评价手段.方法 2017年12月至2018年6月,20例健康成年人完成词与图分屏呈现任务(任务1)和同屏呈现任务(任务2),比较在匹配与不匹配情况下事件相关电位(ERP)N400的特征.结果 最终纳入14例.任务1诱发的N400波峰出现更早,振幅更高;在中央顶枕部N400激活强度更大,且诱发更大的N170、P1波;两任务在多数脑区目标时段匹配与不匹配N400振幅差有显著性差异(t＞2.319,P＜0.05).结论 有工作记忆参与的词图匹配语言任务可更好地调动语言相关脑区处理信息.模拟汉语语言康复场景的实验任务可作为客观评价指标.
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